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Mission: Immunity | Your Mission Report
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*In reality, MHC proteins do not come to the surface without a peptide. However, for recognizing protein structures
and interactions, the challenge to distinguish an 'empty' MHC from a 'loaded' one seems worth including.
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<td><font face="Verdana, Arial, Helvetica, sans-serif" size="4">Welcome back to Mission Control! This report gathers your findings from the cell surface and asks for your decision on the fate of the cell.</font></td>
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<body bgcolor="rgb(230, 230, 230)" marginwidth="5" marginheight="5">
<strong><font face="Arial, Helvetica, sans-serif" size="4">How many MHC
proteins did you find on the cell surface? </font></strong>
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<strong><font face="Arial, Helvetica, sans-serif" size="4">How many MHC
proteins were holding peptides*?<br><br></font></strong>
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<body bgcolor="rgb(230, 230, 230)" marginwidth="5" marginheight="5">
<strong><font face="Arial, Helvetica, sans-serif" size="4">Below are some
sequences of "self" peptides. Place a check mark next to any sequence you
found on an MHC protein on the cell.</font></strong>
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LEU-MET-GLN-ASP-ILE-ASN-TYR-PRO-THR
THR-PRO-TYR-ASN-ILE-ASP-GLN-MET-LEU
LEU-MET-GLN-ASN-ILE-ASP-TYR-PRO-THR
THR-PRO-TYR-ASP-ILE-ASN-GLN-MET-LEU
THR-TYR-ASP-ILE-ASN-GLN-MET-LEU
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<body bgcolor="rgb(230, 230, 230)" marginwidth="5" marginheight="5">
<strong><font face="Arial, Helvetica, sans-serif" size="4">Below are some
sequences of "non-self" peptides. Place a check mark next to any sequence
you found on an MHC protein on the cell.</font></strong>
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ILE-GLY-VAL-PRO-ARG-ARG-TYR-SER-SER
SER-SER-TYR-ARG-ARG-PRO-VAL-GLY-ILE
ILE-GLY-VAL-PRO-ARG-TYR-SER
SER-TYR-ARG-PRO-VAL-GLY-ILE
SER-TYR-ARG-ARG-PRO-VAL-GLY-ILE
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<font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b>Title: </b>An
MHC protein with peptide<br><b>Task: </b>Double-click the image and use
the annotation tool (<img src="annotation.gif">) to label the peptide.</font>
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<body marginwidth="5" marginheight="5">
<font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b>Title: </b>Another
MHC protein with peptide<br><b>Task: </b>Double-click the image and use
the annotation tool (<img src="annotation.gif">) to label the peptide.</font>
</body>
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<body bgcolor="rgb(230, 230, 230)" marginwidth="5" marginheight="5">
<strong><font face="Arial, Helvetica, sans-serif" size="4">Given what you
found on the cell surface, explain whether the cell should be destroyed or
allowed to live, and why:</font></strong>
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