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Protein Folding: Page 12
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<p class="pagetitle"><strong>Protein Folding:</strong> Quaternary Structure</p>
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<td><img src="chargeMainIdea.png" width="98" height="58"></td>
<td><p class="mainidea">Proteins can made of two or more separate strings of amino acids. These can be identical, or completely different from each other, or a mixture of some identical and some different.</p></td>
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<p class="subhead">
Multi-Subunit Proteins
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<p class="firstp">
Some proteins have a fourth, or <b>quaternary</b>, level of structure.
Quaternary structure occurs when proteins come together to form a
complex that functions as a unit. For example, alcohol dehydrogenase
(featured on the previous page) only functions when two copies of the
same protein chain work together.
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<p class="firstp" align="center">
<b>Examples of Quaternary Structure</b> </p> </td>
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<tr>
<td colspan="2">
<br>
<b>First, load a protein using the "Load" buttons. Then click its Play button to watch a movie.</b></td>
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<td style="width: 15%" align="right">
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</td>
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<td colspan="2">
<input value="Load Homodimer" id="button3" script="script:jmol:1:load 1HTB.pdb;" type="submit" name="button3"></td>
</tr>
<tr> </tr>
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<td valign="top" align="right"><input value="Play" id="button2" script="script:jmol:1:script jmol-adh2-init.spt; script jmol-adh2-movie.spt; script jmol-echoFade.spt; script jmol-adh2-buhbye.spt" type="submit" name="button2"> </td>
<td>
Alcohol Dehydrogenase has 2 identical subunits making up one working protein (a<b> homodimer</b>)<br><br> </td>
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<td colspan="2">
<br><input value="Load Heterotrimer" id="button4" script="script:jmol:1:load 1GG2.pdb;" type="submit" name="button4">
</td>
</tr>
<tr> </tr>
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<td align="right" valign="top"><input value="Play" id="button1" script="script:jmol:1:script jmol-gprot-init.spt; script jmol-gprot-movie.spt; script jmol-echoFade.spt; script jmol-gprot-buhbye.spt" type="submit" name="button1"> </td>
<td>
This G Protein has 3 different subunits making one working protein (a<b>
heterotrimer</b>) </td>
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This protein is called Tumor Necrosis Factor, or TNF for short. When it
is activated, it can trigger the death of tumor cells. It is used by our
immune systems to fight cancer.
</p>
<p>
<b>Use your mouse and these controls </b>to explore this protein's
structure. Then answer the questions below.
</p>
<div align="center">
<p>
<b>Molecule Style and Color: </b><br>
<select script4="script:jmol:2:set echo off; script jmol-p2-foldsProtein.spt" script3="script:jmol:2:set echo off;script jmol-p2-aminoAcidsBeads.spt" script2="script:jmol:2:set echo off; restrict none; select all; cartoon;" script1="script:jmol:2:set echo off; script jmol-p2-allAtomsSpacefill.spt">
<option>spacefill
<option>ribbons
<option>amino acid beads
<option>tubes
</select>
<br>
<select script4="script:jmol:2:set echo off; select all; color cpk" script3="script:jmol:2:set echo off; isosurface off; select all; color monomer;" script2="script:jmol:2:set echo off; select all; color structure;" script1="script:jmol:2:set echo off; select all; color white;" script5="script:jmol:2:set echo off; select protein; color chain;">
<option>monocolor
<option>secondary structure
<option>end-to-end rainbow
<option>element
<option>subunit
</select>
</p>
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<p class="question">
Does TNF have the quaternary level of structure? Make sure to try
different color schemes on the model of TNF above).
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true
yes
no
it's impossible to tell.
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Explain your answer to the previous question:
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