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An Experiment on a Hydrophobic-Hydrophilic-Mixed Polypeptide
Protein Folding
[positive charge-red; negative charge-green; neutral-white; hydrophobic-pink; hydrophilic-cyan; water-blue; oil-yellow]
Explore the effects of changing the solvent and the types of amino acids on protein structure.
Remember to control the variables that you change (one at a time) and to record your observations in a systematic way.
Proteins are composed of both hydrophobic and hydrophilic residues that runs in an order specified by genetic code. How an array of amino acids folds up into a particular shape is a very complex issue --- it is precisely this complexity that results in the diversity of the biological world. We are of course not trying to lead you to understand this issue, but what the model is capable of showing might be helpful for you to understand some aspects of protein structures.
To access the Amino Acid Mutation Menu, hold down the ALT key and click on a "bead".
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Generate a random self-avoided conformation
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Generate a random self-avoided polypeptide conformation
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