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Activity Title: Page 6
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<strong>Proteins III:</strong> Responding to Adrenaline
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How does a receptor protein receive a signal?
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<b>When you are startled by an unexpected loud noise or very sudden
movement, you can feel a surge of energy traveling through your body
- a "shot of adrenaline".</b> Adrenaline is a small
molecule secreted under stress, and it travels rapidly through the
bloodstream. Cells with adrenaline receptors receive a signal and
prepare you to run or to stand and fight if necessary.
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In response to adrenaline, your heart rate increases,
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pumping more oxygen-carrying blood to your muscles. In addition,
adrenaline casues sugar to be released into your bloodstream,
fueling your muscles and brain, and causes digestion and other
normal functions to stop, so you can focus all your energy on a
potential threat or crisis.
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<p class="firstp">
Adrenaline receptor proteins are embedded in the membranes of cells that
respond to adrenaline. As adrenaline travels through your body's
bloodstream, it is recognized by the adrenaline receptor's binding site.
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Show how the receptor sits in the cell membrane<br>
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View the adrenaline binding site (<a href="script:page:0:message adrenalineAnalog.html">What's
in there?</a>)<br>
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Do you think adrenaline is a charged molecule? How can you tell?
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The surface of adrenaline's binding site is blue, indicating that it is negatively charged. Therefore adrenaline must be positively charged, or it would not be attracted to the site.
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Why is it important that adrenaline fits closely inside its binding site?
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A close fit allows for intermolecular interactions to form so that adrenaline can be held securely by its receptor.
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