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Protein Conservation 6
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Amino Acid Similarity
Use the Amino Acid Side Chain Properties Chart to find:
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<font face="verdana, arial, helvetica, sans-serif" size="5">When side
chain "personalities" are similar, an amino acid substitution in a protein
may be harmless, and can be passed on to future generations. This is how,
over millions of years, proteins evolve. The more similar two protein
sequences are, the more likely they are to perform the same or a similar
function. To understand the chemical aspects of what we mean by
similarity, you can use descriptions of amino acid properties and compare
amino acid structures.</font>
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<font face="Verdana, Arial, Helvetica, sans-serif" color="rgb(051, 051, 051)" size="5"><strong>Searching
for Side Chain Similarities</strong></font>
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<font face="verdana, arial, helvetica, sans-serif" size="4"><b>Side
Chain Properties</b><br><br>The similarities and differences between
side chains come down to the variation of a few properties. These
include:</font>
<ul>
<li>
<font face="verdana, arial, helvetica, sans-serif" size="4">size</font>
</li>
<li>
<font face="verdana, arial, helvetica, sans-serif" size="4">shape</font>
</li>
<li>
<font face="verdana, arial, helvetica, sans-serif" size="4">polarity</font>
</li>
</ul>
<font face="verdana, arial, helvetica, sans-serif" size="4">But how
different are they?<!-- Use the <b><a target="_blank" href="aa_props.png">Side
Chain Properties chart</a></b>, to compare amino acid
similairities and differences. -->
Use the link below to open the <b>Side Chain Properties chart</b>
to compare amino acid similairities and differences. </font>
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<img height="252" src="aa_still.png" width="407">
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1. <b>two similar amino acids</b> that are small and hydrophobic.
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2. <b>two similar amino acids</b> that are positively charged.
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3. <b>two similar amino acids</b> that are polar (but not charged) and
small (but not tiny).
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