Challenge 2: make a mutation that causes NO property change
Try out substitutions that replace one hydrophobic amino acid with another.

1. Press reset ( ) to get back the original DNA sequence.
2. Make a new substitution mutation somewhere in the sequence. Make the mutation to a codon that codes for a hydrophobic amino acid (any but the first), to see if the resulting amino acid is still hydrophobic.
3. Synthesize your new protein, and take a snapshot. Use the arrow annotation tool to indicate where you made your mutation. Is the new amino acid hydrophobic?
4. Optional: repeat this process a few times, to see how often you get a change from hydrophobic to hydrophilic. It should be not very often.

Return to Challenge #1.